Journal of Cancer Research Updates

Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity
Pages 60-64
Chao-Zhan Lin, Ai-Zhi Wu, Ying Zhong, Yu-Mei Wang, Guang-Tian Peng, Xian-Jun Su, Bing-Xin Liu, Yun Deng, Chen-Chen Zhu and Cui-Xian Zhang


Published: 07 May 2015


Abstract: In clinical, Psychotria serpens L. was often substitute for Caulis trachelospermi to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In order to search significant anti-cancer active leading compounds, sevenetin (5),rutin (6),kaempferol-3- flavonoids, quercetin(1),tamarixetin-3-O-rutinoside (2),quercetin 3-O-(2G-β-D- xylopyranosy- lrutinoside) (3), kaempferol(4), tamarixO- rutino- side (7) were isolated from P. serpens L., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS. 2-5 were the first isolated from genus Psychotria. All of compoundswere the first isolated from P. serpens.

Keywords: Psychotria serpens L., anti-cancer, flavonoids.

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