Ventricular Dysfunction Secondary to Refeeding Syndrome in an Infant, A Case Report

Authors

  • Ana M. Aristizabal Fundación Valle del Lili, Departamento Materno Infantil, Servicio de Cardiología Pediátrica. Cra. 98 No. 18 – 49, Cali 760032, Colombia and Universidad Icesi, Facultad de Medicina, Cali, Colombia
  • Carlos A. Guzmán-Serrano Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali - Colombia https://orcid.org/0000-0003-0431-8035
  • Camila Ariza-Insignares Universidad Icesi, Facultad de Medicina, Cali, Colombia https://orcid.org/0000-0002-6989-7587
  • Gerardo Guzmán Fundación Valle del Lili, Departamento Materno Infantil, Unidad de Cuidado Intensivo Pediátrico, Cali, Colombia
  • Claudia Guerrero Fundación Valle del Lili, Departamento Materno Infantil, Servicio de Cardiología Pediátrica. Cra. 98 No. 18 – 49, Cali 760032, Colombia and Universidad Icesi, Facultad de Medicina, Cali, Colombia
  • Cesar Cely Fundación Valle del Lili, Departamento Materno Infantil, Servicio de Cardiología Pediátrica. Cra. 98 No. 18 – 49, Cali 760032, Colombia and Universidad Icesi, Facultad de Medicina, Cali, Colombia

DOI:

https://doi.org/10.6000/1929-4247.2024.13.04.3

Keywords:

Refeeding syndrome, ventricular dysfunction, case report

Abstract

Introduction: Refeeding syndrome is a complex of signs and symptoms that occur following the abrupt initiation of enteral or parenteral nutrition in malnourished patients, among other causes. Most data focuses on adolescents and adults, with limited neonatal information and other pediatric group ages. This case presents an infant who developed ventricular dysfunction due to refeeding syndrome following starvation.

Case Report: A 5-month-old female with a one-month history of generalized maculopapular rash and lower limb edema. Physical examination revealed severe malnutrition and significant electrolyte imbalances. The initial echocardiogram was unremarkable. Despite nutritional and dermatological management, the patient developed respiratory distress, generalized edema, and anuria, necessitating Pediatric Intensive Care Unit admission. Subsequent echocardiograms revealed dilated cardiomyopathy with systolic-diastolic dysfunction. After receiving inodilator therapy and diuretics, her condition temporarily improved but deteriorated again, requiring further intensive care. Imaging ruled out significant structural heart disease, and after a prolonged hospital stay, the patient was eventually stabilized and discharged with gradual nutritional and growth improvement.

Discussion: Cardiac complications following refeeding have been reported primarily in older patients with comorbidities, unlike our case, hence the rarity. Malnutrition-induced myocardial alterations and the stress of refeeding may have contributed to the observed ventricular dysfunction.

Conclusion: Any malnourished patient should be considered for the potential onset of refeeding syndrome. Risks and complications should not be underestimated despite the patient's age. A multidisciplinary approach is crucial for the proper management of this condition, although its presence does not seem to warrant special considerations for the care of cardiac complications.

References

Boateng AA, Sriram K, Meguid MM, Crook M. Refeeding syndrome: Treatment considerations based on collective analysis of literature case reports. Nutrition 2010; 26(2): 156-67. https://doi.org/10.1016/j.nut.2009.11.017 DOI: https://doi.org/10.1016/j.nut.2009.11.017

Byrnes MC, Stangenes J. Refeeding in the ICU: an adult and pediatric problem: Current Opinion in Clinical Nutrition and Metabolic Care 2011; 14(2): 186-92. https://doi.org/10.1097/MCO.0b013e328341ed93 DOI: https://doi.org/10.1097/MCO.0b013e328341ed93

Miller SJ. Death Resulting From Overzealous Total Parenteral Nutrition: The Refeeding Syndrome Revisited. Nut in Clin Prac 2008; 23(2): 166-71. https://doi.org/10.1177/0884533608314538 DOI: https://doi.org/10.1177/0884533608314538

Da Silva JSV, Seres DS, Sabino K, Adams SC, Berdahl GJ, Citty SW, et al. ASPEN Consensus Recommendations for Refeeding Syndrome. Nut in Clin Prac 2020; 35(2): 178-95. https://doi.org/10.1002/ncp.10474 DOI: https://doi.org/10.1002/ncp.10474

Corsello A, Trovato CM, Dipasquale V, Bolasco G, Labriola F, Gottrand F, et al. Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review. Journal of Pediatric Gastroenterology & Nutrition 2023; 77(6): e75-83. https://doi.org/10.1097/MPG.0000000000003945 DOI: https://doi.org/10.1097/MPG.0000000000003945

Cormack BE, Jiang Y, Harding JE, Crowther CA, Bloomfield FH, for the ProVIDe Trial Group. Neonatal Refeeding Syndrome and Clinical Outcome in Extremely Low‐Birth‐Weight Babies: Secondary Cohort Analysis From the ProVIDe Trial. J Parenter Enteral Nutr 2021; 45(1): 65-78. https://doi.org/10.1002/jpen.1934 DOI: https://doi.org/10.1002/jpen.1934

Runde J, Sentongo T. Refeeding Syndrome. Pediatr Ann [Internet] 2019 Nov [cited 2024 Aug 25]; 48(11). Available from: https://journals.healio.com/doi/10.3928/19382359-20191017-02 https://doi.org/10.3928/19382359-20191017-02 DOI: https://doi.org/10.3928/19382359-20191017-02

Bradford CV, Cober MP, Miller JL. Refeeding Syndrome in the Neonatal Intensive Care Unit. The Journal of Pediatric Pharmacology and Therapeutics 2021; 26(8): 771-82. https://doi.org/10.5863/1551-6776-26.8.771 DOI: https://doi.org/10.5863/1551-6776-26.8.771

Adkins SM. Recognizing and Preventing Refeeding Syndrome: Dimensions of Critical Care Nursing 2009; 28(2): 53-8. https://doi.org/10.1097/DCC.0b013e318195d3e0 DOI: https://doi.org/10.1097/DCC.0b013e318195d3e0

Vignaud M, Constantin JM, Ruivard M, Villemeyre-Plane M, Futier E, Bazin JE, et al. Refeeding syndrome influences the outcome of anorexia nervosa patients in intensive care unit: an observational study. Crit Care 2010; 14(5): R172. https://doi.org/10.1186/cc9274 DOI: https://doi.org/10.1186/cc9274

Burns J, Shank C, Ganigara M, Saldanha N, Dhar A. Cardiac complications of malnutrition in adolescent patients: A narrative review of contemporary literature. Annals of Pediatric Cardiology 2021; 14(4): 501-6. https://doi.org/10.4103/apc.apc_258_20 DOI: https://doi.org/10.4103/apc.apc_258_20

Sakamoto Y, Kioka H, Hashimoto R, Takeda S, Momose K, Ohtani T, et al. Cardiogenic shock caused by a left midventricular obstruction during refeeding in a patient with anorexia nervosa. Nutrition 2017; 35: 148-50. https://doi.org/10.1016/j.nut.2016.12.017 DOI: https://doi.org/10.1016/j.nut.2016.12.017

Oud L. Transient hypoxic respiratory failure in a patient with severe hypophosphatemia. Med Sci Monit 2009; 15(3): CS49-53.

Kameoka N, Iga J, Tamaru M, Tominaga T, Kubo H, Watanabe S, et al. Risk factors for refeeding hypophosphatemia in Japanese inpatients with anorexia nervosa. Int J Eating Disorders 2016; 49(4): 402-6. https://doi.org/10.1002/eat.22472 DOI: https://doi.org/10.1002/eat.22472

Miyoshi T, Higashi H, Amemiya K, Ikeda Y, Yamaguchi O. Cardiohistological Findings in Refeeding Syndrome. Cureus [Internet] 2024 Aug 21 [cited 2024 Oct 15]. https://doi.org/10.7759/cureus.67430 DOI: https://doi.org/10.7759/cureus.67430

Frederiks P, Peetermans M, Wilmer A. Nutritional support in the cardiac intensive care unit. European Heart Journal: Acute Cardiovascular Care 2024; 13(4): 373-9. https://doi.org/10.1093/ehjacc/zuae01 DOI: https://doi.org/10.1093/ehjacc/zuae018

Downloads

Published

2024-11-28

How to Cite

Aristizabal, A. M. ., Guzmán-Serrano, C. A. ., Ariza-Insignares, C. ., Guzmán, G. ., Guerrero, C. ., & Cely, C. . (2024). Ventricular Dysfunction Secondary to Refeeding Syndrome in an Infant, A Case Report. International Journal of Child Health and Nutrition, 13(4), 220–224. https://doi.org/10.6000/1929-4247.2024.13.04.3

Issue

Section

General Articles