Vitamin D - Beyond Bones: Its Relationship to Obesity, Metabolic Syndrome, and Diabetes
DOI:
https://doi.org/10.6000/1929-5634.2014.03.03.4Keywords:
Vitamin D, obesity, metabolic syndrome (MetS), diabetes.Abstract
While vitamin D has long been known as an essential nutrient for the prevention of bone disorders, vitamin D deficiency has recently been linked to a number of chronic disease states. This review analyzes the epidemiological, clinical, and mechanistic data concerning the relationship between vitamin D status and obesity, metabolic syndrome (MetS), and diabetes. The increased understanding of the role of vitamin D has promoted researchers to study vitamin D as a potential target for the prevention and treatment of multiple chronic diseases.References
Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003; 78(5): 912-9. DOI: https://doi.org/10.1093/ajcn/78.5.912
Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens 2009; 27(10): 1948-54. http://dx.doi.org/10.1097/HJH.0b013e32832f075b DOI: https://doi.org/10.1097/HJH.0b013e32832f075b
Grandi NC, Breitling LP, Brenner H. Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Prev Med 2010; 51(3-4): 228-33. http://dx.doi.org/10.1016/j.ypmed.2010.06.013 DOI: https://doi.org/10.1016/j.ypmed.2010.06.013
Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 2011; 65(9): 1005-15. http://dx.doi.org/10.1038/ejcn.2011.118 DOI: https://doi.org/10.1038/ejcn.2011.118
Grant WB. How strong is the evidence that solar ultraviolet B and vitamin D reduce the risk of cancer? An examination using Hill's criteria for causality. Dermatoendocrinol 2009; 1(1): 17-24. http://dx.doi.org/10.4161/derm.1.1.7388 DOI: https://doi.org/10.4161/derm.1.1.7388
Schottker B, Haug U, Schomburg L, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 2013; 97(4): 782-93. http://dx.doi.org/10.3945/ajcn.112.047712 DOI: https://doi.org/10.3945/ajcn.112.047712
Vasquez A, Manso G, Cannell J. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med 2004; 10(5): 28-36.
Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 2001; 86(2): 888-94. DOI: https://doi.org/10.1210/jc.86.2.888
Vanlint S. Vitamin D and Obesity. Nutrients 2013; 5: 949-56. http://dx.doi.org/10.3390/nu5030949 DOI: https://doi.org/10.3390/nu5030949
Foss YJ. Vitamin D deficiency is the cause of common obesity. Med Hypotheses 2009; 72(3): 314-21. http://dx.doi.org/10.1016/j.mehy.2008.10.005 DOI: https://doi.org/10.1016/j.mehy.2008.10.005
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87(4): 1080S-6S. DOI: https://doi.org/10.1093/ajcn/87.4.1080S
Matsuoka LY, Ide L, Wortsman J, MacLaughlin JA, Holick MF. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab 1987; 64(6): 1165-8. http://dx.doi.org/10.1210/jcem-64-6-1165 DOI: https://doi.org/10.1210/jcem-64-6-1165
Schwartz GG, Blot WJ. Vitamin D status and cancer incidence and mortality: something new under the sun. J Natl Cancer Inst 2006; 98(7): 428-30. http://dx.doi.org/10.1093/jnci/djj127 DOI: https://doi.org/10.1093/jnci/djj127
Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002; 76(1): 187-92. DOI: https://doi.org/10.1093/ajcn/76.1.187
Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr 2012; 108(4): 692-8. http://dx.doi.org/10.1017/S0007114512001808 DOI: https://doi.org/10.1017/S0007114512001808
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985; 76(4): 1536-8. http://dx.doi.org/10.1172/JCI112134 DOI: https://doi.org/10.1172/JCI112134
Kim MK, Baek KH, Song KH, et al. Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab 2011; 96(10): 3250-6. http://dx.doi.org/10.1210/jc.2011-1602 DOI: https://doi.org/10.1210/jc.2011-1602
Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition 2010; 26(11-12): 1031-7. http://dx.doi.org/10.1016/j.nut.2009.12.003 DOI: https://doi.org/10.1016/j.nut.2009.12.003
Saltzman E, Karl JP. Nutrient Deficiencies After Gastric Bypass Surgery. Annu Rev Nutr 2013. http://dx.doi.org/10.1146/annurev-nutr-071812-161225 DOI: https://doi.org/10.1146/annurev-nutr-071812-161225
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911-30. http://dx.doi.org/10.1210/jc.2011-0385 DOI: https://doi.org/10.1210/jc.2011-0385
Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-81. http://dx.doi.org/10.1056/NEJMra070553 DOI: https://doi.org/10.1056/NEJMra070553
Viard JP, Souberbielle JC, Kirk O, et al. Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study. AIDS 2011; 25(10): 1305-15. http://dx.doi.org/10.1097/QAD.0b013e328347f6f7 DOI: https://doi.org/10.1097/QAD.0b013e328347f6f7
Maria T, Thomas S, Marc VG, Stephane DW. Factors associated with vitamin D deficiency in a population of 2044 HIV-infected patients. Clin Nutr 2013.
Adams JSHM. Hypercalcemia caused by granuloma-forming disorders. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th ed. Washington (DC): American Society for Bone and Mineral Research; 2006; pp. 200-2.
Grey A, Lucas J, Horne A, Gamble G, Davidson JS, Reid IR. Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency. J Clin Endocrinol Metab 2005; 90(4): 2122-6. http://dx.doi.org/10.1210/jc.2004-1772 DOI: https://doi.org/10.1210/jc.2004-1772
Parikh SJ, Edelman M, Uwaifo GI, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89(3): 1196-9. http://dx.doi.org/10.1210/jc.2003-031398
Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003; 88(1): 157-61. http://dx.doi.org/10.1210/jc.2002-020978 DOI: https://doi.org/10.1210/jc.2002-020978
Kamycheva E, Joakimsen RM, Jorde R. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutr 2003; 133(1): 102-6. DOI: https://doi.org/10.1093/jn/133.1.102
Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985; 76(1): 370-3. http://dx.doi.org/10.1172/JCI111971 DOI: https://doi.org/10.1172/JCI111971
Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR. Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr 1981; 34(11): 2359-63. DOI: https://doi.org/10.1093/ajcn/34.11.2359
Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) 2005; 29(4): 391-7. http://dx.doi.org/10.1038/sj.ijo.0802880
Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004; 12(4): 582-90. http://dx.doi.org/10.1038/oby.2004.67
Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89(3): 1196-9. http://dx.doi.org/10.1210/jc.2003-031398 DOI: https://doi.org/10.1210/jc.2003-031398
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690-3. DOI: https://doi.org/10.1093/ajcn/72.3.690
Rajakumar K, de las HJ, Chen TC, Lee S, Holick MF, Arslanian SA. Vitamin D status, adiposity, and lipids in black American and Caucasian children. J Clin Endocrinol Metab 2011; 96(5): 1560-7. http://dx.doi.org/10.1210/jc.2010-2388 DOI: https://doi.org/10.1210/jc.2010-2388
Caron-Jobin M, Morisset AS, Tremblay A, Huot C, Legare D, Tchernof A. Elevated serum 25(OH)D concentrations, vitamin D, and calcium intakes are associated with reduced adipocyte size in women. Obesity (Silver Spring) 2011; 19(7): 1335-41. http://dx.doi.org/10.1038/oby.2011.90 DOI: https://doi.org/10.1038/oby.2011.90
Soares MJ, Chan SP-D, Ghanbari MH. Calcium and vitamin D for obesity: a review of randomized controlled trials. Eur J Clin Nutr 2011; 65(9): 994-1004. http://dx.doi.org/10.1038/ejcn.2011.106 DOI: https://doi.org/10.1038/ejcn.2011.106
Soares MJ, Murhadi LL, Kurpad AV, Chan She Ping-Delfos WL, Piers LS. Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obes Rev 2012; 13(7): 592-605. http://dx.doi.org/10.1111/j.1467-789X.2012.00986.x DOI: https://doi.org/10.1111/j.1467-789X.2012.00986.x
Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women. Nutr J 2012; 11: 78. http://dx.doi.org/10.1186/1475-2891-11-78 DOI: https://doi.org/10.1186/1475-2891-11-78
Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr 2002; 21(2): 146S-51S. http://dx.doi.org/10.1080/07315724.2002.10719212 DOI: https://doi.org/10.1080/07315724.2002.10719212
Zhu W, Cai D, Wang Y, et al. Calcium plus vitamin D3 supplementation facilitated fat loss in overweight and obese college students with very-low calcium consumption: a randomized controlled trial. Nutr J 2013; 12: 8. http://dx.doi.org/10.1186/1475-2891-12-8 DOI: https://doi.org/10.1186/1475-2891-12-8
Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004; 12(4): 582-90.c DOI: https://doi.org/10.1038/oby.2004.67
Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) 2005; 29(4): 391-7. http://dx.doi.org/10.1038/sj.ijo.0802880 DOI: https://doi.org/10.1038/sj.ijo.0802880
Schwartz MW, Niswender KD. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance? J Clin Endocrinol Metab 2004; 89(12): 5889-97. http://dx.doi.org/10.1210/jc.2004-0906 DOI: https://doi.org/10.1210/jc.2004-0906
Zemel MB. Mechanisms of dairy modulation of adiposity. J Nutr 2003; 133(1): 252S-6S. DOI: https://doi.org/10.1093/jn/133.1.252S
Hill JW. Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons. The Open Neuroendocrinology Journal 2010; 3: 21-7.
Vimaleswaran KS, Berry DJ, Lu C, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013; 10(2): e1001383. http://dx.doi.org/10.1371/journal.pmed.1001383 DOI: https://doi.org/10.1371/journal.pmed.1001383
Yin X, Sun Q, Zhang X, et al. Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population. Nutr J 2012; 11: 68. http://dx.doi.org/10.1186/1475-2891-11-68 DOI: https://doi.org/10.1186/1475-2891-11-68
Muldowney S, Lucey AJ, Paschos G, et al. Relationships between vitamin D status and cardio-metabolic risk factors in young European adults. Ann Nutr Metab 2011; 58(2): 85-93. http://dx.doi.org/10.1159/000324600 DOI: https://doi.org/10.1159/000324600
Gagnon C, Lu ZX, Magliano DJ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 2012; 97(6): 1953-61. http://dx.doi.org/10.1210/jc.2011-3187 DOI: https://doi.org/10.1210/jc.2011-3187
Minambres I, Sanchez-Hernandez J, Sanchez-Quesada JL, Rodriguez J, de LA, Perez A. The association of hypovitaminosis d with the metabolic syndrome is independent of the degree of obesity. ISRN Endocrinol 2012; 2012: 691803. DOI: https://doi.org/10.5402/2012/691803
Fung GJ, Steffen LM, Zhou X, et al. Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr 2012; 96(1): 24-9. http://dx.doi.org/10.3945/ajcn.112.036863 DOI: https://doi.org/10.3945/ajcn.112.036863
Maki KC, Fulgoni VL, III, Keast DR, Rains TM, Park KM, Rubin MR. Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003-2006. Metab Syndr Relat Disord 2012; 10(5): 363-72. http://dx.doi.org/10.1089/met.2012.0020 DOI: https://doi.org/10.1089/met.2012.0020
Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007; 167(11): 1159-65. http://dx.doi.org/10.1001/archinte.167.11.1159 DOI: https://doi.org/10.1001/archinte.167.11.1159
Reis JP, von MD, Miller ER, III, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 2009; 124(3): e371-e379. http://dx.doi.org/10.1542/peds.2009-0213 DOI: https://doi.org/10.1542/peds.2009-0213
Rodriguez-Rodriguez E, Ortega RM, Gonzalez-Rodriguez LG, Lopez-Sobaler AM. Vitamin D deficiency is an independent predictor of elevated triglycerides in Spanish school children. Eur J Nutr 2010; 50(5): 373-8. http://dx.doi.org/10.1007/s00394-010-0145-4 DOI: https://doi.org/10.1007/s00394-010-0145-4
Ponda MP, Huang X, Odeh MA, Breslow JL, Kaufman HW. Vitamin D may not improve lipid levels: a serial clinical laboratory data study. Circulation 2012; 126(3): 270-7. http://dx.doi.org/10.1161/CIRCULATIONAHA.111.077875 DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.077875
Ponda MP, Dowd K, Finkielstein D, Holt PR, Breslow JL. The short-term effects of vitamin D repletion on cholesterol: a randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2012; 32(10): 2510-5. http://dx.doi.org/10.1161/ATVBAHA.112.254110 DOI: https://doi.org/10.1161/ATVBAHA.112.254110
Barger-Lux MJ, Heaney RP, Lanspa SJ, Healy JC, DeLuca HF. An investigation of sources of variation in calcium absorption efficiency. J Clin Endocrinol Metab 1995; 80(2): 406-11. DOI: https://doi.org/10.1210/jcem.80.2.7852497
Lacour B, Basile C, Drueke T, Funck-Brentano JL. Parathyroid function and lipid metabolism in the rat. Miner Electrolyte Metab 1982; 7(3): 157-65.
Kohno M, Takahashi S, Oida K, et al. 1 alpha,25-dihydroxyvitamin D3 induces very low density lipoprotein receptor mRNA expression in HL-60 cells in association with monocytic differentiation. Atherosclerosis 1997; 133(1): 45-9. http://dx.doi.org/10.1016/S0021-9150(97)00112-3 DOI: https://doi.org/10.1016/S0021-9150(97)00112-3
von Hurst PR, Stonehouse W, Matthys C, Conlon C, Kruger MC, Coad J. Study protocol-metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention. BMC Public Health 2008; 8: 267. http://dx.doi.org/10.1186/1471-2458-8-267 DOI: https://doi.org/10.1186/1471-2458-8-267
von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr 2010; 103(4): 549-55. http://dx.doi.org/10.1017/S0007114509992017 DOI: https://doi.org/10.1017/S0007114509992017
George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med 2012; 29(8): e142-e150. http://dx.doi.org/10.1111/j.1464-5491.2012.03672.x DOI: https://doi.org/10.1111/j.1464-5491.2012.03672.x
Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013; 97(4): 774-81. http://dx.doi.org/10.3945/ajcn.112.050013 DOI: https://doi.org/10.3945/ajcn.112.050013
Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005; 48(7): 1247-57. http://dx.doi.org/10.1007/s00125-005-1802-7 DOI: https://doi.org/10.1007/s00125-005-1802-7
Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 1995; 27(3): 181-8. http://dx.doi.org/10.1016/0168-8227(95)01040-K DOI: https://doi.org/10.1016/0168-8227(95)01040-K
Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27(12): 2813-8. http://dx.doi.org/10.2337/diacare.27.12.2813 DOI: https://doi.org/10.2337/diacare.27.12.2813
Kabadi SM, Lee BK, Liu L. Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care 2012; 35(10): 2048-54. http://dx.doi.org/10.2337/dc12-0235 DOI: https://doi.org/10.2337/dc12-0235
Mattila C, Knekt P, Mannisto S, et al. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007; 30(10): 2569-70. http://dx.doi.org/10.2337/dc07-0292 DOI: https://doi.org/10.2337/dc07-0292
Kumar S, Davies M, Zakaria Y, et al. Improvement in glucose tolerance and beta-cell function in a patient with vitamin D deficiency during treatment with vitamin D. Postgrad Med J 1994; 70(824): 440-3. http://dx.doi.org/10.1136/pgmj.70.824.440 DOI: https://doi.org/10.1136/pgmj.70.824.440
Isaia G, Giorgino R, Adami S. High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care 2001; 24(8): 1496. http://dx.doi.org/10.2337/diacare.24.8.1496 DOI: https://doi.org/10.2337/diacare.24.8.1496
Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 1994; 37(6): 552-8. http://dx.doi.org/10.1007/BF00403372 DOI: https://doi.org/10.1007/BF00403372
Sooy K, Schermerhorn T, Noda M, et al. Calbindin-D(28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines. J Biol Chem 1999; 274(48): 34343-9. http://dx.doi.org/10.1074/jbc.274.48.34343 DOI: https://doi.org/10.1074/jbc.274.48.34343
Sandler S, Buschard K, Bendtzen K. Effects of 1,25-dihydroxyvitamin D3 and the analogues MC903 and KH1060 on interleukin-1 beta-induced inhibition of rat pancreatic islet beta-cell function in vitro. Immunol Lett 1994; 41(1): 73-7. http://dx.doi.org/10.1016/0165-2478(94)90059-0 DOI: https://doi.org/10.1016/0165-2478(94)90059-0
Vaidya A, Williams JS, Forman JP. The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: the NHS and the HPFS. Obesity (Silver Spring) 2012; 20(1): 186-91. http://dx.doi.org/10.1038/oby.2011.210 DOI: https://doi.org/10.1038/oby.2011.210
Wolfson N, Gavish D, Matas Z, Boaz M, Shargorodsky M. Relation of adiponectin to glucose tolerance status, adiposity, and cardiovascular risk factor load. Exp Diabetes Res 2012; 2012: 1-5. http://dx.doi.org/10.1155/2012/250621 DOI: https://doi.org/10.1155/2012/250621
Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89(5): 552-72. http://dx.doi.org/10.1079/BJN2003837 DOI: https://doi.org/10.1079/BJN2003837
Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999; 69(5): 842-56. DOI: https://doi.org/10.1093/ajcn/69.5.842
Taylor WH, Khaleeli AA. Coincident diabetes mellitus and primary hyperparathyroidism. Diabetes Metab Res Rev 2011; 17(3): 175-80. http://dx.doi.org/10.1002/dmrr.199 DOI: https://doi.org/10.1002/dmrr.199
Beilfuss J, Berg V, Sneve M, Jorde R, Kamycheva E. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects. Cytokine 2012; 60(3): 870-4. http://dx.doi.org/10.1016/j.cyto.2012.07.032 DOI: https://doi.org/10.1016/j.cyto.2012.07.032
Peterson CA, Heffernan ME. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond) 2008; 5: 10. http://dx.doi.org/10.1186/1476-9255-5-10 DOI: https://doi.org/10.1186/1476-9255-5-10
Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Kalayi A, et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab Res Rev 2012; 28(5): 424-30. http://dx.doi.org/10.1002/dmrr.2290 DOI: https://doi.org/10.1002/dmrr.2290
Shedeed SA. Vitamin D supplementation in infants with chronic congestive heart failure. Pediatr Cardiol 2012; 33(5): 713-9. http://dx.doi.org/10.1007/s00246-012-0199-6 DOI: https://doi.org/10.1007/s00246-012-0199-6
Bucharles S, Barberato SH, Stinghen AE, et al. Impact of cholecalciferol treatment on biomarkers of inflammation and myocardial structure in hemodialysis patients without hyperparathyroidism. J Ren Nutr 2012; 22(2): 284-91. http://dx.doi.org/10.1053/j.jrn.2011.07.001 DOI: https://doi.org/10.1053/j.jrn.2011.07.001
Hopkins MH, Owen J, Ahearn T, et al. Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: a randomized, controlled clinical trial. Cancer Prev Res (Phila) 2011; 4(10): 1645-54. http://dx.doi.org/10.1158/1940-6207.CAPR-11-0105 DOI: https://doi.org/10.1158/1940-6207.CAPR-11-0105
Sergeev I, Song Q. High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res 2014; 58(6): 1342-8. http://dx.doi.org/10.1002/mnfr.201300503 DOI: https://doi.org/10.1002/mnfr.201300503
Soskic S, Stokic E, Isenovic E. The relationship between vitamin D and obesity. CMRO 2014; 30(6): 1197-9. http://dx.doi.org/10.1185/03007995.2014.900004 DOI: https://doi.org/10.1185/03007995.2014.900004
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- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .
