Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete
DOI:
https://doi.org/10.6000/1929-5634.2015.04.03.1Keywords:
Canadian goldenrod, Solidago altissima, antitumour promotion, two-stage carcinogenesis, cancer preventionAbstract
Cancer prevention is an important issue in various healthcare fields; thus, we continue searching for potential useful compounds. This study focuses on the utilization of Canadian goldenrod, which is commonly seen growing on vacant land. Methanol extracts of the flower of Canadian goldenrod inhibited inflammation by 12-O-tetradecanoylphorbol-13-acetate (TPA) and inhibited promotion in the mouse skin two-stage carcinogenesis model. Five inhibitory compounds were isolated from the active fraction, and these compounds were identified as flavonoids; kaempferol (1), quercetin (2), kaempferol-3-O-rutinoside (3), querectin-3-O-rutinoside (4), and isorhamnetin-3-O-rutinoside (5). These compounds inhibited the inflammation induced by TPA, and the inhibitory effects were similar to indomethacin.
References
Yasukawa K. Medicinal and edible plants as caner preventive agents. In: Drug discovery research in pharmacognosy. Eds. Vallisuta O, Olimat SM. InTech, Rijeka 2012; 181-208. http://dx.doi.org/10.5772/34545
Yasukawa K. Edible and medicinal mushrooms as promising agents in cancer. In: Drug discovery and development — From molecules to medicine. Eds. Vallisuta O, Olimat SM. InTech, Rijeka 2015; 39-61. http://dx.doi.org/10.5772/59964
Iinuma M, Matsuura S, Kusuda K. 13C-Nuclear magnetic resonance (NMR) spectral studies on polysubstituted flavonoids. I. 13C-NMR spectra of flavones. Chem Pharm Bull 1980; 28: 708-16. http://dx.doi.org/10.1248/cpb.28.708
Markham KR, Ternai B, Stanley R, Geiger H, Mabry TJ. Carbon-13 NMR studies of flavonoids ― III. Naturally occurring flavonoid glycosides and their acylated derivatives. Tetrahedron 1978; 34: 1389-97. http://dx.doi.org/10.1016/0040-4020(78)88336-7
Kaminaga T, Yasukawa K, Takido M, Tai T, Nunoura Y. Inhibitory effect of Poria cocos on 12-O-tetradecanoylphorbol-13-acetate- induced ear oedema and tumour promotion in mouse skin. Phytother Res 1996; 10: 581-4. http://dx.doi.org/10.1002/(SICI)1099-1573(199611)10:7<581::AID-PTR907>3.0.CO;2-3
Kasahara Y, Kumaki K, Katagiri S, Yasukawa K, Yamanouchi S, Takido M, Akihisa T, Tamura T. Carthami Flos extract and its component, stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis. Phytother Res 1994; 8: 327-31. http://dx.doi.org/10.1002/ptr.2650080603
Yasukawa K, Sun Y, Kitanaka S, Tomizawa N, Miura M, Motohashi S. Inhibitory effect of the Rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin. J Nat Med 2008; 62: 374-8. http://dx.doi.org/10.1007/s11418-008-0243-2
Yasukawa K, Yu S-Y, Tsutsumi S, Kurokawa M, Park YK. Inhibitory effects of Brazilian propolis on tumor promotion in two-stage mouse skin carcinogenesis. J Pharm Nutr Sci 2012; 2: 71-6. http://dx.doi.org/10.6000/1927-5951.2012.02.01.10
Yasukawa K, Okuda S, Nobushi Y. Inhibitory effect of gymnema (Gymnema sylvestre) leaves on tumour promotion in two-stage mouse skin carcinogenesis. eCAM 2014; 328684. http://www.hindawi.com/journals/ecam/2014/328684
Yasukawa K, Kitanaka S, Kawata K, Goto K. Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. Fitoterapia 2009; 80: 164-7. http://dx.doi.org/10.1016/j.fitote.2009.01.006
Yasukawa K, Takido M, Takeuchi M, Nakagawa S. Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol-13-acetate- induced inflammation in mice. Chem Pharm Bull (Tokyo) 1989; 37: 1071-3. http://dx.doi.org/10.1248/cpb.37.1071
Nishino, H, Iwashima A, Fujiki H, Sugimura T. Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. Gann 1984; 75: 113-6.
Kato R, Nakadate T, Yamamoto S, Sugimura T. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis 1983; 4: 1301-5. http://dx.doi.org/10.1093/carcin/4.10.1301
Yasukawa K, Takido M, Takeuchi M, Sato Y, Nitta K, Nakagawa S. Inhibitory effects of flavonol glycosides on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Chem Pharm Bull (Tokyo) 1990; 38: 774-6. http://dx.doi.org/10.1248/cpb.38.774
Nakadate T, Yamamoto S, Aizu E, Kato R. Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Gann 1984; 75: 214-22.
Scott KA, Moore RJ, Arnott CH. An anti-tumor necrosis factor-α antibody inhibits the development of experimental skin tumors. Mol Cancer Ther 2003; 2: 445-51. http://mct.aacrjournals.org/content/2/5/445.long
Fujiki H, Sueoka E, Suganuma M. Tumor promoters: from chemicals to inflammatory proteins. J Cancer Res Clin Oncol 2013; 139: 1603-14. http://dx.doi.org/10.1007/s00432-013-1455-8
Chen T-J, Jeng J-Y, Lin C-W, Wu C-Y, Chen Y-C. Quercetin inhibition of ROS-dependent and –independent apoptosis in rat glioma C6 cells. Toxicology 2006; 223: 113-26. http://dx.doi.org/10.1016/j.tox.2006.03.007
Chen T-J, Shen S-C, Lin H-Y, Chien L-L, Chen Y-C. Lipopolysaccharide enhancement of 12-O-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. Toxicol Lett 2004; 147: 1-13. http://dx.doi.org/10.1016/j.toxlet.2003.10.012
Lin C-W, Hou W-C, Shen S-C, Juan S-H, Ko C-H, Wang L-M, Chen Y-C. Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 2008; 29: 1807-15. http://dx.doi.org/10.1093/carcin/bgn162
Park BK, Lee S, Seo J-N, Rhee JW, Park J-B, Kim Y-S, Choi I-G, Kim Y-E, Lee Y, Kwon H-J. Protection of burn-induced skin injuries by the flavonoid kaempferol. BMB Reports 2010; 43: 46‒51. http://dx.doi.org/10.5483/BMBRep.2010.43.1.046
Downloads
Published
How to Cite
Issue
Section
License
Policy for Journals/Articles with Open Access
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work
Policy for Journals / Manuscript with Paid Access
Authors who publish with this journal agree to the following terms:
- Publisher retain copyright .
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .
