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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Depressive symptoms and occurrence of type 2 diabetes major depression dating site Japanese men. The information provided in this site is intended for US healthcare professionals only.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Eighty participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders DSM-5 criteria for major depressive disorder MDD will be stratified by study site and randomized with a 1-to-1 allocation under double-blind conditions to receive a single 25 mg oral dose of psilocybin or a single mg oral dose of niacin.

Niacin will serve as an active placebo. The purpose of this study is to evaluate the potential efficacy of a single 25 mg oral dose of psilocybin for MDD compared to the active placebo in otherwise medically-healthy participants, assessed as the difference between groups in changes in depressive symptoms from Baseline to Day 8 post-dose.

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