Fe(III)-Chloroquine Complex: A New Potent Compound in Wellness Industries of High Antimicrobial and Antimalarial Activities

Deepa Thakur; Jyotsna Mishra; K. S. Pitre; Smita Joshi

doi:10.6000/1927-3037.2013.02.03.5

Fe(III)-Chloroquine Complex: A New Potent Compound in Wellness Industries of High Antimicrobial and Antimalarial Activities

Authors

Deepa Thakur Department of Chemistry, Sarojni Naidu Girls P.G. Collage, Bhopal, MP, India
Jyotsna Mishra Department of Chemistry, Scope College of Engineering, Bhopal, MP, India
K. S. Pitre Department of Chemistry, Dr. H.S. Gour University, Sagar, MP, India
Smita Joshi Department of Chemistry, Sarojni Naidu Girls P.G. Collage, Bhopal, MP, India

DOI:

https://doi.org/10.6000/1927-3037.2013.02.03.5

Keywords:

Fe (III) â€“ Antimicrobial activity, Antimalarial activity, in vivo study

Abstract

Fe(III)- Chloroquine complex has been synthesized and screened for its physicochemical, microbial as well as pharmacological activity have been done in solid and aqueous phase. On the basis of elemental analysis, polarographic studies, amperometric titration and IR spectral studies the probable formula for the complex has been determined at 25±1^OC and ionic strength of µ= 1.0[KCl]. Raper’s paper disc method was used for microbial study against various pathogenic bacteria and fungi. In vivo syudy of Swiss mice [25-30gm] were used for antimalarial activity against Chloroquine and its complex on xyline-Alcoholic activity test Kidney, liver and serum of these rats were also studied. On the basis of observed result it could be concluded that Fe (III)-Chloroquine complex were found to be non-toxic and more potent than pure chloroquine drug.

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Published

2013-09-30

How to Cite

Thakur, D., Mishra, J., Pitre, K. S., & Joshi, S. (2013). Fe(III)-Chloroquine Complex: A New Potent Compound in Wellness Industries of High Antimicrobial and Antimalarial Activities. International Journal of Biotechnology for Wellness Industries, 2(3), 140–144. https://doi.org/10.6000/1927-3037.2013.02.03.5

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Vol. 2 No. 3 (2013)

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