Relationship between the rs333 Polymorphism in the CC Chemokine Receptor Type Five (CCR5) Gene and Immunological Disorders: Data from a Meta-Analysis

Authors

  • Felipe Rodolfo Pereira da Silva Post Graduation Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil and Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • Alessandro Luiz Araújo Bentes Leal Laboratory of Biology of Microorganisms, Parnaiba Delta Federal University (UFDPar), Parnaiba, Piaui, Brazil
  • Reyce Santos Koga Post Graduation Program in Public Health, University of São Paulo, São Paulo, Brazil
  • Even Herlany Pereira Alves Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • John Arlley Sousa Pinho de Lira Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • Humbelina Alves da Silva Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • Karen Neisman Rodríguez Ayala Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • Paulo Roberto Carneiro Gomes Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil
  • Anna Carolina Toledo da Cunha Pereira Laboratory of Biology of Microorganisms, Parnaiba Delta Federal University (UFDPar), Parnaiba, Piaui, Brazil
  • Daniel Fernando Pereira Vasconcelos Laboratory of Histological Analysis and Preparation (LAPHis), Parnaiba Delta Federal University (UFDPar), Parnaiba, PI, Brazil

DOI:

https://doi.org/10.6000/1929-6029.2021.10.08

Keywords:

Cytokine, inflammation, autoimmune disease, genetic variation

Abstract

Introduction: Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are multifactorial diseases, one of the factors in the course of these diseases is the rs333 polymorphism in the CC chemokine receptor type five (CCR5) gene. However, the results remain contradictory. Therefore, we aimed to perform a meta-analysis evaluating the relation between this polymorphism and the aforementioned conditions.

Material and Methods: A search in the literature was performed in diverse scientific and medical databases for studies published before June 22, 2020. The data were extracted from the studies and the statistical evaluation was performed by the calculations of statistical heterogeneity (I²), Odds Ratio (OR) with 95% of Confidence Intervals (CI) and publication bias. The values of P<0.05 were considered as significant for all calculations.

Results: 19 articles with 21 case/control studies in 4,304 case patients and 3,492 controls were included. The meta-analysis showed a non-significant association among the rs333 polymorphism and IBD (OR = 1.05, 95% CI: 0.91-1.20, P = 0.51), periodontitis (OR = 0.86, 95% CI: 0.64-1.17, P = 0.34) or SLE (OR = 1.00, 95% CI: 0.56-1.80, P = 1.00) under the allelic model or for any other performed calculation. There were no obvious publication bias in the analyses.

Conclusion: In conclusion, this current meta-analysis evidenced the non-significant relation among the rs333 polymorphism and the risk of IBD, periodontitis or SLE. Further studies are required to validate our data.

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2021-09-20

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Pereira da Silva, F. R. ., Bentes Leal, A. L. A. ., Koga, R. S., Pereira Alves, E. H. ., Pinho de Lira, J. A. S. ., Alves da Silva, H. ., Rodríguez Ayala, K. N. ., Carneiro Gomes, P. R. ., Cunha Pereira, A. C. T. da ., & Pereira Vasconcelos, D. F. . (2021). Relationship between the rs333 Polymorphism in the CC Chemokine Receptor Type Five (CCR5) Gene and Immunological Disorders: Data from a Meta-Analysis. International Journal of Statistics in Medical Research, 10, 85–96. https://doi.org/10.6000/1929-6029.2021.10.08

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