Effects of some Biological Covariates on the Probability of First Recurrence of Malaria following Treatment with Artemisinin Combination Therapy

Authors

  • Cletus Kwa Kum Mathematics/Computer Science Department, Faculty of Science, P.O. Box 67 Dschang, University of Dschang, Cameroon
  • Daniel Thorburn Department of Statistics, Stockholm University, Sweden
  • Gebrenegus Ghilagaber Department of Statistics, Stockholm University, Sweden
  • Anders Björkman Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
  • José Pedro Gil Drug Resistance Unit, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden

DOI:

https://doi.org/10.6000/1929-6029.2018.07.01.1

Keywords:

Logistic model, clinical covariates, malaria treatment, parasite density, drug resistance, genotype, incomplete data

Abstract

Many investigations have shown that artemisinin-based combination therapies are effective in the treatment of uncomplicated malaria and that they do not increase parasite resistance to treatment as much as treatment with single substance. We study the relation between some biological covariates and the time to first recurrence of malaria for children treated for malaria in a clinical trial. One group received artesunate plus sulfadoxine-pyrimethamine and the other only sulfadoxine-pyrimethamine. We consider the event malaria-free for the first 42 (and 84) days. We use logistic regression models for the analyses. The main results show that the probability of no recurrence is higher if the parasite density in the blood is high. The results are inconclusive for other explanatory biological variables. The infecting parasites having genes that indicate resistance, gave different results at the two different treatment centres. There was no appreciable difference in the effects of treatment over the two follow-up periods and these treatments do not have any effect on the probability of a recurrence

References

Mårtensson A, Ngasala B, Ursing J, et al. Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania. The Journal of Infectious Diseases 2007; 195(4): 597-601. https://doi.org/10.1086/510910 DOI: https://doi.org/10.1086/510910

Okell LC, Cairns M, Griffin JT, et al. Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis. Nature Communications 2014; 5. https://doi.org/10.1038/ncomms6606 DOI: https://doi.org/10.1038/ncomms6606

Yavo W, Konaté A, Kassi FK, et al. Efficacy and safety of Artesunate-Amodiaquine versus Artemether-Lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sentinel sites across Côte D’Ivoire. Malaria Research and Treatment 2015; 2015.

http://dx.doi.org/10.1155/2015/878132 DOI: https://doi.org/10.1155/2015/878132

Kum CK, Thorburn D, Ghilagaber G, Gil P, Björkman A. A nonparametric bayesian approach to estimating malaria prophylactic effect after two treatments. International Journal of Statistics in Medical Research 2013; 2(2): 76-87.

http://dx.doi.org/10.6000/1929-6029.2013.02.02.01 DOI: https://doi.org/10.6000/1929-6029.2013.02.02.01

Kum CK, Thorburn D, Ghilagaber G, Gil P, Björkman A. On the effects of malaria treatment on parasite drug resistance–probability modelling of genotyped malaria infections. The International Journal of Biostatistics 2013; 9(1): 135-48. https://doi.org/10.1515/ijb-2012-0016 DOI: https://doi.org/10.1515/ijb-2012-0016

Mårtensson A. PCR adjusted cure rates in clinical trials of antimalarial drugs in Africa: Influence of extended follow-up and consecutive day blood sampling. PhD thesis, Institutionen för medicin/Department of Medicine 2008.

Hosmer Jr DW, Lemeshow S, Sturdivant RX. Applied Logistic Regression. John Wiley & Sons 2013. https://doi.org/10.1002/9781118548387 DOI: https://doi.org/10.1002/9781118548387

Doolan DL, Dobaño C, Baird JK. Acquired immunity to malaria. Clinical Microbiology Reviews 2009; 22(1): 13-36. https://doi.org/10.1128/CMR.00025-08 DOI: https://doi.org/10.1128/CMR.00025-08

Gupta S, Snow RW, Donnelly CA, Marsh K, Newbold C. Immunity to non-cerebral severe malaria is acquired after one or two infections. Nature Medicine 1999; 5(3): 340-3. https://doi.org/10.1038/6560 DOI: https://doi.org/10.1038/6560

Griffin JT, Hollingsworth TD, Reyburn H, Drakeley CJ, Riley EM, Ghani AC. Gradual acquisition of immunity to severe malaria with increasing exposure. Proceedings of the Royal Society of London B: Biological Sciences 2015; 282(1801): 20142657.

http://dx.doi.org/10.1098/rspb.2014.2657 DOI: https://doi.org/10.1098/rspb.2014.2657

Ittarat W, Pickard AL, Rattanasinganchan P, et al. Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors. The American Journal of Tropical Medicine and Hygiene 2003; 68(2): 147-52. https://doi.org/10.4269/ajtmh.2003.68.147 DOI: https://doi.org/10.4269/ajtmh.2003.68.147

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Published

2018-02-06

How to Cite

Kum, C. K., Thorburn, D., Ghilagaber, G., Björkman, A., & Gil, J. P. (2018). Effects of some Biological Covariates on the Probability of First Recurrence of Malaria following Treatment with Artemisinin Combination Therapy. International Journal of Statistics in Medical Research, 7(1), 1–9. https://doi.org/10.6000/1929-6029.2018.07.01.1

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