Elevated Lactate as a Mortality Factor in Poly Traumatised Patients: A Systematic Review and Meta-Analysis

Authors

  • Bryam Martin Gómez Carrasco Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú https://orcid.org/0000-0002-4871-3144
  • Oswaldo Gómez Carrasco Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú
  • Gerard Gómez Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú
  • Rubén Espinoza-Rojas Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú https://orcid.org/0000-0002-1459-3711
  • Cori Raquel Iturregui-Paucar Universidad Tecnológica del Perú, Lima, Perú
  • Luisa Erika Milagros Vásquez-Romero Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú
  • Fiorella E. Zuzunaga-Montoya Universidad Científica del Sur, Lima, Perú
  • Víctor Juan Vera-Ponce Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú https://orcid.org/0000-0003-4075-9049
  • Jhony A. De La Cruz-Vargas Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú https://orcid.org/0000-0002-5592-0504

DOI:

https://doi.org/10.6000/1929-6029.2023.12.10

Keywords:

Lactic acid, mortality, multiple trauma, Systematic review, Hospital mortality, Patient Admission (Source: MeSH NLM)

Abstract

Introduction: According to global health estimates from the World Health Organization (WHO) injuries represent 8% of world deaths. There are systematic reviews that relate lactate and mortality in trauma patients but do not focus on multiple trauma patients.

Objective: To determine if elevated lactate is a mortality factor in multiple trauma patients.

Methodology: A systematic review and meta-analysis of observational studies were carried out. The search was carried out in 4 databases: PUBMED, Embase, Scopus, and Web of Science.

Data were pooled using a random effects model and summary statistics were calculated using odds ratios (ORs) with their respective 95% confidence intervals (95% CI).

Results: Nine studies were included (n=5302). A significant association was found between elevated admission lactate with mortality (OR: 1.80; 95% CI 1.11 to 2.91) and 72-hour mortality (OR: 1.24; 95% CI 1.02 to 1.50). No statistically significant association was found for the analysis of elevated admission lactate and 28-day mortality (OR: 1.24; 95% CI 1.02 to 1.50). Finally, elevated admission lactate is associated with mortality regardless of time (OR: 1.34; 95% CI 1.19 to 1.50).

Conclusion: Elevated admission lactate is associated with mortality and 72-hour mortality in multiple trauma patients. No significant association was found between elevated admission lactate and 30-day mortality. Elevated intake of lactate is associated with mortality independent of time.

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Published

2023-07-11

How to Cite

Gómez Carrasco, B. M. ., Carrasco, O. G. ., Gómez, G. ., Espinoza-Rojas, R. ., Iturregui-Paucar, C. R. ., Vásquez-Romero, L. E. M. ., Zuzunaga-Montoya, F. E. ., Vera-Ponce, V. J. ., & Cruz-Vargas, J. A. D. L. . (2023). Elevated Lactate as a Mortality Factor in Poly Traumatised Patients: A Systematic Review and Meta-Analysis. International Journal of Statistics in Medical Research, 12, 73–81. https://doi.org/10.6000/1929-6029.2023.12.10

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