Table of Contents

Volume 4 No. 4, 2015

* This issue includes papers published with  

Synthesis of Stable Sols of Layered Titanate Nanoparticles using Dialysis and Applications for Thin Film Preparation - Pages 165-172
Chun Ming Wen, Takashi Kojima and Naofumi Uekawa
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.04.1

Thermodynamic Investigation of NaClO3 Solubility in the Mixed Solvent Medium and the Related Ion – Pair Formation at Different Temperatures - Pages 173-177
Mehran Aghaie and Roshanak Kishani
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.04.2

Volumetric Study of the Binary Mixtures Containing a Branched Hexane and an Isomeric Chlorobutane - Pages 178-184
Hernando Guerrero, Félix M. Royo and Carlos Lafuente
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.04.3

New Conditions of Saturation of Aqueous Solutions for the Modeling of Regions of Solid Phases - Pages 185-193
R.A. Yusupov, Z.T. Dinh and S.A. Bakhteev
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.04.4

A Thermodynamic Model on a Linear Rule between the Molal Concentration Exponential and the Osmotic Coefficients on Mole Fraction Base in Electrolyte Solutions and its Application - Pages 194-212
Zheng Fang
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.04.5

Table of Contents

Volume 4 No. 2, 2015

Benzothiazole-Based Bis-azo Cationic Fluorescent Dyes with Extended Conjugated Systems: Synthesis and Properties - Pages 83-94
Frahnaz Nourmohammadian, Mohammad Yousef Alikhani, Mahnaz Davoudzadeh Gholami and Ali Ashtiani Abdi
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.1

Polymeric Versus Lipid Nanoparticles: Comparative Study of Nanoparticulate Systems as Indomethacin Carriers - Pages 95-109
Ana Carvalho, Ivo Lopes, Odete Gonçalves, Eduarda Bárbara, M. Elisabete C.D. Real Oliveira and Marlene Lúcio
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.2

Preferential Solvation of the Antioxidant Agent Daidzein in some Aqueous Co-Solvent Mixtures according to IKBI and QLQC Methods - Pages 110-118
Daniel M. Jiménez, Zaira J. Cárdenas, Daniel R. Delgado, María Á. Peña and Fleming Martínez
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.3

Study of Molecular Interactions in Binary Mixtures of Diethyl Carbonate + Benzene Derivatives at Different Temperatures - Pages 119-127
K. Narendra, B. Sudhamsa, M. Sarath Babu and T.S. Krishna
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.4

The Influence of Solvent on Complex Formation of Crown Ether with Tetraphenylphosphonium Chloride - Pages 128-131
Atri Deo Tripathi
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.5

Table of Contents

Volume 4 No. 3, 2015

Structural Data, Linear and Nonlinear Optical Properties of Some Cyclic Phosphazenes: A Theoretical Investigation - Pages 132-142
D. Hadji and A. Rahmouni
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.03.1

Thermodynamic Modeling of Chiral Compounds Solubility Using Correlative and Predictive Models - Pages 143-151
Morteza Salimi, Bahman Zarenezhad, Hossein Fakhraian and Ebrahim Choobdari
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.03.2

Free Unsolvated Formaldehyde in Solutions: Influence of Temperature, Solvent Permittiity, and Total Formaldehyde Concentration - Pages 152-159
Michael M. Silaev
DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.03.3

Excess Molar Enthalpies of Mixtures of Acetylene Tetrachloride with Dimethylsulfoxide, Acetone, Acetonitrile and N-Dibutyl Ether at 303.15 K - Pages 160-164
Atri D. Tripathi and Shalini Choudhary

Polymeric Versus Lipid Nanoparticles: Comparative Study of Nanoparticulate Systems as Indomethacin Carriers
Pages 95-109
Ana Carvalho, Ivo Lopes, Odete Gonçalves, Eduarda Bárbara, M. Elisabete C.D. Real Oliveiraand Marlene Lúcio

DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.02.2

Published: 16 June 2015

Abstract: Encapsulation of nonsteroidal or non-steroidal anti-inflammatory drugs (NSAID) in nanocarrier systems aims to enhance bioavailability and to decrease toxicity of these drugs and thus improve the efficacy of treatments. With this aim two types of nanoparticles were prepared and compared: lipid nanoparticles, made of cetyl palmitate and Miglyol 812 which were uncoated or coated with chitosan; or polymeric nanoparticles, made of poly (DL-lactic-co-glycolic acid) (PLGA) for which different emulsion stabilizers were also tested (poly (vinyl alcohol) (PVA), and Pluronic F68). Nanoparticles were characterized for drug content and for particle size, charge and morphology. The lipid matrix was analyzed regarding its crystallinity by differential scanning calorimetry (DSC). The size of the nanoparticles was measured by dynamic light scattering (DLS) which indicated a unimodal particle size distribution in all systems. Nanoparticles’ stability was confirmed by their highly negative surface charge in the case of polymeric and uncoated lipid nanoparticles, as analyzed by zeta potential measurements using electrophoretic light scattering (ELS). Lipid chitosan coated nanoparticles have also shown to be stable presenting highly positive surface charge. Results have further demonstrated that indomethacin is highly encapsulated regardless the type of particles. Morphological analysis by scanning electron microscopy has shown that the nanoparticles were smooth and spherical.

The results gathered within the current study point to the conclusion that the proposed formulations provide nanoparticles of satisfactory quality to encapsulate indomethacin, which might be used to improve bioavailability of other NSAID in the treatment of inflammation.

Keywords: NSAID, PLGA nanoparticles, nanostructured lipid carriers (NLC), encapsulation efficiency, dynamic and electrophoretic light scattering (DLS and ELS), differential scanning calorimetry (DSC), electron scanning microscopy (SEM).