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Abstract : Relationship Between Vitamin D and Cardio-Metabolic Biomarkers Among Saudi Postmenopausal Women
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Abstract: Vitamin D deficiency is prevalent worldwide, and in Saudi Arabia in particular. There is growing evidence that hypovitaminosis D is involved in the pathogenesis of cardiovascular diseases. We determined concentrations of serum 25 hydroxy 25(OH) vitamin D in relation to several metabolic biomarkers including total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol, triglycerides (TG), atherogenic index (AI), glucose, C-reactive protein (CRP), adiposity, and blood pressure in a cross-sectional analysis in 300 Saudi postmenopausal women. Participants completed a detailed questionnaire and fasting blood samples were collected. Vitamin D deficiency was common, affecting 89% of individuals. Higher serum 25(OH) vitamin D levels were consistently found among subjects with no prevalent cardiovascular risk factors (p>0.05) except for those subjects with serum CRP level ≥3mg/dl, HDL-C <1.04mmol/L, AI≥5, exercising ≥3times/week, and those with 4 or more pregnancies. Hypovitaminosis D was inversely correlated with DBP (r=-0.118, p=0.042), TC (r=-0.165, p=0.004), TG (r=-0.119, p=0.040), LDL-C (r=-0.138, p=0.017), AI (r=-0.125, p=0.031), and veiling type (r=-0.127, p=0.028). No significant impact of hypovitaminosis D on CRP, levels of which were similar among vitamin D sufficient and deficient subjects. However, hypovitaminosis D was significantly related to dyslipidemia and diastolic blood pressure in a group of Saudi postmenopausal women. Keywords: HypovitaminosisD, cardiovascular risk factors, Saudi postmenopausal women.Download Full Article |
Abstract : Cellular Mechanisms of Saline Extract of Alligator Pepper (Zingiberaceae Aframomum melegueta) for Specific Protection against Preeclampsia
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Abstract: Preeclampsia is a clinical syndrome defined as the new onset of hypertension and proteinuria during the second half of pregnancy. Though it is easily diagnosed clinically, affected persons must book in a health service facility for the diagnosis to be made. Furthermore regular screening is necessary during several antenatal visits and skilled attendant’s supervised labor before diagnosis can be made. Predictive tests are not yet well developed and not readily available in developing countries and medically underserved areas where they are needed most. There is therefore a need for specific protection against preeclampsia to be developed. This will ensure that all women are protected even when they choose not to visit an antenatal clinic. Specific protection is potentially capable of preventing preeclampsia in 5 % to 7% of pregnant women, the proportion of pregnant women that are affected by preeclampsia worldwide. This article builds on a previous article on the study of the cellular mechanisms underlying gestational weight gain and litter weight reduction effect of aqueous extract of Alligator pepper and attempts to analyze how the anti-hyperinsulinemic property of the constituents of Alligator pepper in that study can also prevent preeclampsia and suggests the use of some of the constituents of alligator pepper as specific protection (vaccine) for the prevention of preeclampsia. Keywords: Cellular Mechanisms, Alligator pepper, Preeclampsia, Specific protection.Download Full Article |
Abstract : Effects of Inoculants (Chlorobium limicola and Rhodopseudo-monas palustris) on Nutrient Uptake and Growth in Cucumber
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Abstract: Rhizobacteria is a prosperous for promoting plant growth for the superiority of reducing environmental damages. Two Strains of Chlorobium limicola and Rhodopseudomonas palustris were supplied in the experiment as potential inoculants for cucumber. Significant enhancement of the availability of macronutrient elements N, P and K were observed in soil, and further improvement on the uptake of them was also obtained in cucumberplants. Accumulation of essential micronutrients of Fe and Zn were detected both in roots and in shoots. The two stains increased chlorophylland carotinoid synthesis, plant height, stem diameter, wet weight and dry weight. Various dose has significantly effect on plant growth stimulation, C. Limicola with 107 cells mL-1 and R. Palustris with 108 cells mL-1 seem to be better on the whole. Keywords: Biofertilizer, cucumber, growth, nutrien.Download Full Article |
Abstract : Biomolecule Damage (DNA and Lipid) is Elevated in Patients with Type 1 Diabetes with and without Diabetic Complications
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Abstract: There is strong evidence that oxidative stress is involved in the aetiology and pathogenesis of diabetes and its complications. Increased production of reactive oxygen species in vivo can lead to cellular biomolecule damage, such as lipid peroxidation and DNA damage. The aim of this study was to determine the extent of this damage by measuring in vivo antioxidant status, levels of lipid peroxidation, and levels of neutrophil DNA damage in 50 participants with type 1 diabetes and 50 age- and sex-matched, healthy controls. Gylcaemic control (%HbA1c) was relatively good with a group mean of 7.71% which increased to 8.12 % in those with complications. Compared to the control group there were significantly elevated levels of neutrophil DNA damage (% tail DNA, p<0.0001) and plasma MDA levels (p<0.05) in the Type 1 group as a whole, this significance rose to p<0.01 in those with complications. There were significant alterations in markers of antioxidant status including, reduced levels of superoxide dismutase (p<0.0001), uric acid (p<0.05) and Vitamin C (p<0.05) and elevated levels of catalase (p<0.001). These results indicate that even with acceptable glycaemic control significant oxidative damage still occurs and this damage increases, in some indices, with the onset of complications. Keywords: DNA damage, Type 1 Diabetes, Lipid damage, Glycaemic control, oxidative stress. |
