Carboxylated Magnetite Composite Polymer Nanoparticles with Mosaic Structure for Biomedical Application
Pages 127-133
Kesavarao Sykam and Shailaja Donempudi

DOI: http://dx.doi.org/10.6000/1929-5995.2015.04.02.5

Published: 28 July 2015

Abstract: In this article, a microemulsion method for preparation of magnetite composite polymer nanoparticles of Fe₃O₄@poly(styrene-methacrylic acid) (MNP@PSMA) crosslinked with1,6-hexanediol diacrylate (HDD) insitu with carboxyl functionality on the surface has been reported. Structure and morphology of the nanoparticles was studied by Fourier Transform Infrared spctroscopy (FTIR), X ray Diffraction (XRD), Thermal Gravimetric Analyser (TGA), Vibrating Sample Magnetometer (VSM) and Transmission Electron Microscopy (TEM). VSM studies confirmed saturation magnetization of 20.0 emu/g in an external magnetic field. Nanoparticles formed were of 30 nm in diameter with narrow size distribution and mosaic structure providing a large surface area useful for application in bioseparation. Experimental results of covalent coupling of composite nanoparticles indicated maximum protein binding capacity of 350 mg bovine serum albumin (BSA) per gram.