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Abstract : A Review of the Relationship between Wine Consumption and Type 2 Diabetes Mellitus
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Abstract: The potential health benefits of moderate alcohol consumption are not limited to a reduced risk of cardiovascular disease but are also observed for type 2 diabetes mellitus. The relationship appears to be J-shaped where moderate alcohol consumption reduces the risk of developing type 2 diabetes mellitus in both men and women, irrespective of age, and in those with a low and a high body mass index. The optimal amount of wine appears to be approximately two drinks per day, where a standard drink in Australia is considered to be 10 g alcohol. Given that the incidence of diabetes is projected to approximately double in the next 15 years, simple dietary supplementation to a healthy diet and lifestyle to reduce the risk will become increasingly important. This paper reviews the association between wine specifically and type 2 diabetes mellitus, and discusses biological mechanisms related to the association.. Keywords: Wine, alcohol, resveratrol, diabetes phenolic compound, consumption.Download Full Article |
Abstract : Short Communication: Metabolic Syndrome and Adaptogenic Nutritional Supplement “AdMax”
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Abstract: Metabolic syndrome manifestations include chronic fatigue, insulin resistance, elevated levels of glucose, lipids and cholesterol in the blood, and overweight. The main targets of nutritional supplement “AdMax” are the activation of energy metabolism and stress counteraction. In addition, the “AdMax” constituents decrease the concentration of blood glucose, enhance glucose utilization by cells, decrease the activity of triglyceride lipase and lower blood cholesterol levels. Comparison of metabolic syndrome manifestations to the activities of “AdMax” constituents argues that “AdMax” can be used as a preventive and treatment remedy for metabolic syndrome. Keywords: Metabolic syndrome, Adaptogenic plants, Nutritional supplement “AdMax”, “AdMax” properties, Prevention of Metabolic syndrome.Download Full Article |
Abstract : Safety and Efficacy of Long-Term Use of Extended Release Cornstarch Therapy for Glycogen Storage Disease Types 0, III, VI, and IX
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Abstract: Background: Impaired glycogen release with fasting results in hypoglycemia in the glycogen storage diseases. A waxy-maize extended release cornstarch was introduced in the United States in 2012 to maintain glucose concentrations during the overnight period, but no studies have assessed the long-term safety and efficacy of this product in the ketotic forms of GSD. Objective: To assess long-term safety and efficacy of modified cornstarch in patients with ketotic forms of GSD. Design: An open label overnight trial of extended release cornstarch was performed. Subjects who had a successful trial (defined as optimal metabolic control lasting 2 or more hours more than with traditional cornstarch) were given the option of continuing into the long-term observational phase. Participants were assessed biochemically at baseline and after 12 months. Results: A total of 16 subjects participated in the open label trial. Efficacy was demonstrated in 100% of the subjects with GSD 0, III, VI, and IX. Of the patients who entered the longitudinal phase, long-term data are available for all subjects. The mean duration of overnight fasting on traditional cornstarch prior to the study for the cohort was 4.9 hours and 9.6 hours on the extended release cornstarch (P < 0.001). All laboratory markers of metabolic control have remained stable in the chronically treated patients. Conclusion: Extended release cornstarch dramatically prolongs the overnight fast duration, maximizes safety from hypoglycemic events, reduces the possibility of sleep deprivation, and improves the quality of life of patients by eliminating the need to awaken without fail for middle of the night therapy without sacrificing metabolic control. Keywords: Glycogen storage disease, uncooked cornstarch, extended release cornstarch, ketotic hypoglycemia.Download Full Article |
Abstract : Inhibitory Effects of Ginseng (Panax ginseng)Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA
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Abstract: Cancer prevention is a major issue in the field of public health. Ethanol extracts of the ginseng berry were found to inhibit the inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumour promoter. The extracts also inhibited tumour promotion by TPA in the mouse skin two-stage carcinogenesis model. The major components, ginsenosides Rd (3) and Re (4), inhibited inflammation induced by TPA in mice, while protopanaxadiol (1) and protopanaxatriol (2), the aglycones of these ginsenosides, markedly inhibited TPA-induced inflammatory ear oedema in mice. The inhibitory effects of these compounds were more potent than those of indomethacin. Keywords: Cancer chemoprevention, antitumour-promoting activity, two-stage carcinogenesis, ginsenosides, Panax ginseng.Download Full Article |
