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Abstract : Antioxidant and Anticancer Activities of Raspberry Extracts
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Abstract: The raspberry (Rubus idaeus) is an economical important berry crop that contains phytochemicals such as polyphenols and flavonoids with potential health benefits. This study addresses the antioxidant and anticancer effects of raspberry and its root extracts. Raspberry and raspberry root were extracted with ethanol, and separated into petroleum ether, chloroform, ethyl acetate, n-butyl alcohol and water fraction. Most extracts showed the powerful activities to scavenge DPPH radical, eliminate hydroxyl free radical ion, and inhibit the growth of human cancer cells, suggesting their promising application on health care. Keywords: Raspberry, antioxidant, anticancer. Download Full Article |
Abstract : Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity
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Abstract: In clinical, Psychotria serpens L. was often substitute for Caulis trachelospermi to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In order to search significant anti-cancer active leading compounds, sevenetin (5),rutin (6),kaempferol-3- flavonoids, quercetin(1),tamarixetin-3-O-rutinoside (2),quercetin 3-O-(2G-β-D- xylopyranosy- lrutinoside) (3), kaempferol(4), tamarixO- rutino- side (7) were isolated from P. serpens L., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS. 2-5 were the first isolated from genus Psychotria. All of compoundswere the first isolated from P. serpens. Keywords: Psychotria serpens L., anti-cancer, flavonoids. Download Full Article |
Abstract : Tea and Cancer Prevention
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Abstract: Cancer remains one of the biggest challengesin the 21st century, therefore anti-cancer drugs and their delivery systems are under developing for better treatment. Tea is the amazing gift nature offered to us with great health benefits. Tea polyphenols especially EGCG and Theoflavins have widely been studied and expected to be a very promising nature polyphenol for the prevention of cancer, cardiology disease, aging, weight control etc. Here “Dr. Tea” summarized the past studies about tea and cancer prevention, through the chemical composition, structure, epidemiologic study and mechanism analysis. And based on the epidemiologic study results, a layer-by-layer multi-functional drug delivery system and synergy studies based on our past scientific working experience had been proposed for future tea and cancer research. A “Healthy, Harmony, Pure & Nature” tea-style of living is proposed for all human-beings towards a better living “self” and a better society. Keywords: Tea, cancer prevention, Bohea Tea, polyphenol, drug delivery system, synergy, layer-by-layer, multi-functional, tea-style, “Dr. Tea”, Healthy, Harmony, Pure and Nature. Download Full Article |
Abstract : The Clinical Efficacy and Safety of Paclitaxel in Adjuvant Therapy of Breast Cancer: A Systematic Review and Meta-Analysis
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Abstract: Purpose: To systematically review the clinical efficacy and adverse reactions of Paclitaxel for the treatment of mammary cancer. Math: We searched Web of knowledge, PubMed, VIP information and CNKI (to October 2013) on randomised controlled trial about Paclitaxel for the treatment of mammary cancer and retrieved relevant reference and research material by hand. Two authors independently screened document, extracted data and assessed the quality according to inclusion and exclusion criteria, we finally used the software RevMan 5.2 from Cochrane for Meta-analysis. Result: 18 randomized controlled clinical study were brought into our study according to inclusion and exclusion criteria, including 10712 patients. The result of meta-analysis showed that the odds ratios of Paclitaxel for adjunctive therapy [OR = 1.64, 95% CI (1.40, 1.92), P <0.00001] was better than conventional drugs, while the overall survival was no significant difference between Paclitaxel and conventional drugs. The further Subgroup analysis showed that the efficacy of Paclitaxel for adjunctive therapy was better than cyclophosphamide [OR = 1.41, 95%C I (1. 07, 1.85), P =0. 01] and NVB [OR = 2.10, 95% CI (1.33, 3.30), P =0.001]. The adverse reactions analysis results showed the ratio of myelosuppression and alopecia by treated with Paclitaxel was improved, while the occurrence of gastrointestinal reaction rate was decreased. Conclusion: The current evidence showed Paclitaxel was effective for the adjuvant treatment of breast cancer, but the above conclusions still need future expansion of more samples, high quality RCT verify. Keyword: Paclitaxel, Breast cancer, efficacy, adverse reactions, systematically review, Meta-analysis, randomized controlled trial. Download Full Article |
