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Journal of Intellectual Disability - Diagnosis and Treatment

Hormonal and Psycho-Emotional Disorders in Women with Psychogenic Amenorrhea - Pages 31-36

Vadym N. Goncharenko

DOI: https://doi.org/10.6000/2292-2598.2019.07.02.1


Published: 11 May 2019

 


Abstract: The pathogenetic aspects of stress on reproductive health and fertility of a woman are multi-vector, this is justified by the need for timely diagnosis and the development of new approaches to differentiated treatment of PA.

Objective: to determine the characteristics of the hormonal profile, the psycho-emotional state and changes in the bioelectric activity of the brain in women with stress-induced psychogenic amenorrhea (PA).

Material and Methods: The main group included 54 women with PA from 19 to 37 years, the control group – 25 healthy women from 18 to 35 years. Blood plasma FSH, LH, E2, P, Pr, DHEAS, C levels were checked by the immuno-enzymatic method, bioelectric activity measurement of the brain – with an electroencephalography, women psycho-emotional status – by the Spielberg-Hanin test, statistical data processing was performed using Windows SPSS 11.5. and was carried out by means of standard methods.

Results: Patients were divided on 3 subgroups depend on significant (р<0.05) Prl or C or their combination levels increasing. The presence of nonspecific signs of activation of the structures of the brain stem in patients with PA was established by EEG with significantly (р<0.05) higher frequency. The analysis of the psycho-emotional status of women showed a high level of personal and reactive anxiety.

Conclusions: The revealed features of hormonal imbalance and psycho-emotional status in women with PA indicate the necessity of involving adjacent specialists - neurologists and psychotherapists for timely and adequate examination with the appointment of differentiated pathogenetically substantiated treatment.

Keywords: Psychogenic amenorrhea, hormonal profile, psycho-emotional state, bioelectric activity of the brain.

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Journal of Intellectual Disability - Diagnosis and Treatment

Transition to College for Students with Autism Spectrum Disorder: Needs and Facilitation Strategies. Is Virtual Reality a Useful Tool in the Transition Process? - Pages 37-46

Jorge Fernández Herrero and Gonzalo Lorenzo Lledó

DOI: https://doi.org/10.6000/2292-2598.2019.07.02.2

Published: 11 May 2019

 


Abstract: The number of Autism Spectrum Disorder (ASD) postsecondary students going to University is increasing. Nonetheless, these students face more difficulties than their neuro-typical peers, due to their communication and behaviour impairments. This fact is widely recognized worldwide, and there is an increasing concern in providing them with adequate support both in their transition and beyond. The purpose of this paper is twofold. Firstly, to provide an overall summary of the general requirements of ASD students in the postsecondary education transition with strategies for facilitation, and, secondly, to analyse the possibilities of Virtual Reality (VR) as a support instrument in the transition process. We rely on a brief review of the literature to summarize the main needs and current strategies. In spite of the increasing concern, there is room for establishing general protocols to help the transition process. The use VR in fulfilling this task appears limited, but it seems to be promising.

Keywords: ASD, Autism, University, College, Virtual Reality.

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Journal of Intellectual Disability - Diagnosis and Treatment

Study of a Nano-Oleuropein’s Effect on the TCA Cycle`s Protein Expression in the Breast Cancer Cell Line Using Proteomics - Pages 47-52

Kamrani Solmaz, Khatere Tooba and Mohammad Zaefizadeh

DOI: https://doi.org/10.6000/2292-2598.2019.07.02.3


Published: 11 May 2019

 


Abstract: Breast cancer is the most common cancer and a common cause of death, which occurs due to cancer among women in the world. Cancer cells need a lot of energy to their uncontrolled growth, so it seems that the expression of the enzyme in the Krebs cycle is changing. There are some reports about mutations and altered expression of succinate dehydrogenase, fumarate Hydratase, and isocitrate dehydrogenase in human cancers. This research aimed to investigate the role of magnetite nanoparticle Oleuropein on the Krebs cycle proteins expression on the breast cancer cell line. Oleuropein is one of the polyphenolic components in olive trees and has some benefits in some diseases, including cancer. In addition to testing the viability test MTT (3- 4,5 Dimethylthiazol-2-yl -2,5-diphenyltetrazolium bromide) assay, in three levels of Oleuropein 0ppm, 300ppm, 600ppm proteomics analysis was also performed in cell line MCF7 in this study. The results of differential protein spots identification into two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS-MALDI-TOF-TOF), showed that fumarylacetoacetate hydrolase, succinate-coenzyme A ligase and isocitrate dehydrogenase1 are differential proteins upregulated after treated with 300ppm and 600ppm of oleuropein. It seems that Nano Oleuropein is a booster of Krebs cycle with upregulation of Fumarylacetoacetase, succinate-CoA ligase, and isocitrate dehydrogenase1. Uncoordinated Overexpression of some Krebs cycle protein can be one of the inhibition mechanisms on the breast cancer cell line under Oleuropein treatment.

Keywords: Breast cancer, Oleuropein, Krebs cycle, Proteomics.

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Journal of Intellectual Disability - Diagnosis and Treatment

Role of Multimedia in Depicting the Social Issues of People with ID - Pages 53-56

Alimzhanova Aikerim Bolatovna, Issabek Nurdaulet Erkinuly, Zhaxylykbaeva Rimma Serikalievna, Kamzin Kaken Khamzauly and Mukhamedzhanov Dauren

DOI: https://doi.org/10.6000/2292-2598.2019.07.02.4
Published: 11 June 2019

 


Abstract: This research paper discusses the role of multimedia journalism in depicting the social issues of people with intellectual disabilities and how modern multimedia supports them.

This study aimed to examine how multimedia supports people with intellectual disabilities and how it helps people cope with this problem. The survey covered the year 2017.

The purpose of this qualitative study was to produce an overview of topics and practical recommendations that have been presented for multimedia journalism students to cooperate with the problem of people with ID, how to conduct assistance and highlight their issues in media.

The topic was widely studied, and the outline was made by focusing on the practical implications of research articles. The implications for practice and research are presented based on the findings of this study.

Keywords: Social issues, multimedia journalism, media, new technology, Genesis, specification, special needs, ID.

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