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Effect of Dexmedetomidine-Induced Sleep Balance Treatment on the Chronic Refractory Primary Insomnia Patients DOI: http://dx.doi.org/10.6000/1927-5129.2014.10.15 Published: 17 April 2014 |
Abstract: Aim:To pilot study the therapeutic effect of dexmedetomidine-induced sleep balance treatment (DISBT) on the chronic refractory primary insomnia patients. Methods:Forty-two patients with chronic refractory primary insomnia were randomly divided into two groups by random number table. Patients in DISBT group were given DISBT for 3 days, while patients in the control group were given conventional treatment for 3 day. Pittsburgh sleep quality index (PSQI), the hyperarousal scale (HAS), and Hamilton anxiety scale (HAMA) were evaluated and compared between the pre-treatment and post-1-week-treatment. Sleep architecture and electroencephalogram (EEG) spectrum were also recorded and compared pre-treatment and post-treatment. Results:The scores of PSQI and HAMA in both groups after treatment were lower than those before treatment (P < 0.05), DISBT group-reduced degree were higher than those of the control group (P < 0.05). Sleep architecture of Stage 2 sleep proportion, EEG spectrum beta, and gamma relative power value in DISBT group were lower than those before treatment (P < 0.05), Stage 3 sleep proportion and delta relative power value were higher than those before treatment (P < 0.05); Sleep architecture of Stage 2 sleep proportion,beta, and gamma relative power value in control group were higher than those before treatment (P < 0.05); rapid eye movement sleep, Stage 3 sleep proportion, and delta relative power value were lower than those before treatment (P < 0.05). The total scores of the hyperarousal scale (HAS) in both groups after treatment were lower than those before treatment (P < 0.05), DISBT group-reduced degree were higher than those of the control group (P < 0.05), the extreme score, introspectiveness score, react score of HAS in control group after treatment had no statistical significance compared to those before treatment (P > 0.05), the extreme score, introspectiveness score, react score of HAS in DISBT group after treatment were lower than those before treatment (P < 0.05). Conclusion:DISBT effectively reduced the insomnia patient cortex hyperarousal level, corrected disorder of sleep-awakening pathways and easedup insomnia symptom. It is an effective method for chronic refractory primary insomnia. Keywords: Dexmedetomidine, primary insomnia, hyperarousal.Download Full Article |
Effect of Different Diets on The Development and Morphometric of Coccinella septempunctata (Linneous) DOI: http://dx.doi.org/10.6000/1927-5129.2015.11.65 |
Abstract: A laboratory experiment was carried out to determine the effect of different diets on biology of Coccinella septemputata Linneous, in the Department of Plant protection, Sindh Agriculture University, Tando Jam, Pakistan during 2011 and 2012 at 28±2 ºC and 65±5% relative humidity. The result showed that total larval developmental period was recorded 8.0 ± 0.72 and 7.8 ± 0.69 days on grain moth eggs and safflower aphid, respectively, however, no significant difference was recorded between pre-pupal and pupal period on grain moth egg and safflower aphid. The adult longevity of male (43.10 ± 1.04 and 56.50 ± 1.61) and female (36.07 ± 0.24 and 42.50 ± 0.69 days) was significantly different on grain moth eggs and safflower aphid, respectively. The larval instars were not survived on prepared artificial diet, however, only adult male and female survived (68.50 ± 2.03 and 72.90 ± 2.07 days) without fecundity. The result further revealed that the length and breadth (mm) of larval instars, pupa and adults of C. septempuntata was significantly varied feeding on grain moth eggs and safflower aphid. Keywords: Coccinella septempunctata, development period, morphometric, artificial diets, safflower aphid and grain moth eggs. Download Full Article |